MS 245 oxalate
Cat. No. 4208
Chemical Name: 5-Methoxy-N,N-dimethyl-1-(phenylsul
Biological ActivityHigh affinity 5-HT6 antagonist (Ki = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nirogi et al (2010) Novel and potent 5-piperazinyl methyl-N1-aryl sulfonyl indole derivatives as 5-HT6 receptor ligands. ACS Med.Chem.Lett. 1 340.
Dukat et al (2008) Binding of serotonin and N1-benzenesulfonyltryptamine-related analogs at human 5-HT6 serotonin receptors: receptor modeling studies. J.Med.Chem. 51 603. PMID: 18201064.
Young et al (2006) Effect of the 5-HT6 serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 85 170. PMID: 16950502.
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164.
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Keywords: MS 245 oxalate, supplier, MS245, 5ht6, serotonin, serotonergic, antagonists, Tocris Bioscience, 5-HT6 Receptor Antagonist products
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July 8 - 12, 2017