SB 277011A dihydrochloride

Cat. No. 4207

SB 277011A dihydrochloride C28H30N4O.2HCl [1226917-67-4]

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Chemical Name: N-[trans-4-[2-(6-Cyano-3,4-dihydro-2(1H)-isoquinolinyl)ethyl]cyclohexyl]-4-quinolinecarboxamide dihydrochloride

Biological Activity

Selective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively). Brain penetrant.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Technical Data

Soluble to 5 mM in water and to 50 mM in DMSO
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Reavill et al (2000) Pharmacological actions of a novel, high-affinity, and selective human dopamine D3 receptor antagonist, SB-277011-A. J.Pharmacol.Exp.Ther. 294 1154. PMID: 10945872.

Stemp et al (2000) Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective dopamine D3 receptor antagonist with high oral bioavailability and CNS penetration in the rat. J.Med.Chem. 43 1878. PMID: 10794704.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SB 277011A dihydrochloride include:

Chen et al (2013) Electroacupuncture reduces cocaine-induced seizures and mortality in mice. Nat Neurosci 2013 134610. PMID: 23690833.

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Keywords: SB 277011A dihydrochloride, supplier, SB277011A, dihydrochloride, dopamine, dopaminergic, receptors, antagonists, selective, d3, Tocris Bioscience, D3 Receptor Antagonist products

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