Cat. No. 4204

BTZO 1 C13H8N2OS [99420-15-2]

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Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one

Biological Activity

Macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.

Technical Data

Soluble to 20 mM in DMSO with gentle warming
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282. PMID: 21168764.

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Keywords: BTZO 1, supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective, Tocris Bioscience, Cytokine products

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