BTZO 1

Cat. No. 4204

BTZO 1 C13H8N2OS [99420-15-2]

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Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one

Biological Activity

Macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM). Activates antioxidant response element (ARE)-mediated gene expression. Suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Cardioprotective.

Technical Data

M.Wt:
240.28
Formula:
C13H8N2OS
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
99420-15-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kimura et al (2010) BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitor factor regulates ARE-mediated gene expression. Chem.Biol. 17 1282. PMID: 21168764.

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Keywords: BTZO 1, supplier, BTZO1, mif, macrophage, migration, inhibitory, factors, binders, binds, cardioprotective, Tocris Bioscience, Cytokine products

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