Cat. No. 4202
Chemical Name: 6-Aminopurine hydrochloride
Biological ActivityHigh affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955. PMID: 15604413.
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573.
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Keywords: Adenine, supplier, p0, receptors, agonists, purinergic, signaling, signalling, Tocris Bioscience, Adenine Receptor Agonist products
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