Cat. No. 4202
Chemical Name: 6-Aminopurine hydrochloride
Biological ActivityHigh affinity adenine receptor agonist (Ki = 18 nM at rat adenine receptor). Inhibits forskolin-stimulated cAMP formation in CHO cells transfected with the adenine receptor; also stimulates GTPγS binding (pEC50 values are 8.54 and 7.21 respectively).
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Gorzalka et al (2005) Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. Mol.Pharmacol. 67 955. PMID: 15604413.
Bender et al (2002) Characterization of an orphan G protein-coupled receptor localized in the dorsal root ganglia reveals adenine as a signaling molecule. Proc.Natl.Acad.Sci. 99 8573.
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Keywords: Adenine, supplier, p0, receptors, agonists, purinergic, signaling, signalling, Tocris Bioscience, Adenine Receptor Agonist products