SB 205384

Cat. No. 1512

SB 205384 C17H18N2O3S [160296-13-9]

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Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester

Biological Activity

GABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.

Technical Data

M.Wt:
330.4
Formula:
C17H18N2O3S
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
160296-13-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 Subunits. J.Pharmacol.Exp.Ther. 347 235. PMID: 23902941.

Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522 3. PMID: 10618148.

Meadows et al (1998) SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253. PMID: 9559912.

Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334. PMID: 9257911.

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Citations are publications that use Tocris products. Selected citations for SB 205384 include:

Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235. PMID: 23902941.

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Keywords: SB 205384, supplier, GABAA, receptor, modulators, slows, current, decay, Receptors, SB205384, Tocris Bioscience, GABAA Receptor Modulator products

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