Cat. No. 1512
Chemical Name: 4-Amino-5,6,7,8-tetrahydro-7-hydrox
Biological ActivityGABAA receptor modulator; slows current decay. Potentiates α6, α3 and α5-subunit-containing receptors (EC50 values are 280, 695 and 730 nM respectively). Displays little effect on receptors containing α1 or α2 subunits.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 Subunits. J.Pharmacol.Exp.Ther. 347 235. PMID: 23902941.
Hutcheon et al (2000) Developmental change in GABAA receptor desensitization kinetics and its role in synapse function in rat cortical neurons. J.Physiol. 522 3. PMID: 10618148.
Meadows et al (1998) SB-205384: a GABAA receptor modulator with novel mechanism of action that shows subunit selectivity. Br.J.Pharmacol. 123 1253. PMID: 9559912.
Meadows et al (1997) Effect of SB-205384 on the decay of GABA-activated chloride currents in granule cells cultured from rat cerebellum. Br.J.Pharmacol. 121 1334. PMID: 9257911.
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Citations are publications that use Tocris products. Selected citations for SB 205384 include:
Heidelberg et al (2013) SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 subunit subtypes coexpressed with β3 and γ2 subunits. J Pharmacol Exp Ther 347 235. PMID: 23902941.
Miller et al (2010) Quantitative trait locus analysis identifies Gabra3 as a regulator of behavioral despair in mice. Sci Rep 21 247. PMID: 20512339.
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