C 646

Cat. No. 4200

C 646 C24H19N3O6 [328968-36-1]

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Chemical Name: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl]benzoic acid

Biological Activity

Selective p300/CREB-binding protein (CBP) inhibitor (Ki = 400 nM). Selective against six other histone acetyltransferases (HATs). Suppresses histone H3 and H4 acetylation in mouse fibroblast cell lines.

Technical Data

M.Wt:
445.42
Formula:
C24H19N3O6
Solubility:
Soluble to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
328968-36-1

Resources

Other Information

  • This compound is a mixture of Z:E isomers (~ 80:20)

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Crump et al (2011) Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc.Natl.Acad.Sci. USA 108 7814.

Bowers et al (2010) Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem.Biol. 17 471. PMID: 20534345.

Mali et al (2010) Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28 713. PMID: 20201064.

Ott and Verdi (2010) HAT trick: p300, small molecule, inhibitor. Chem.Biol. 17 417. PMID: 20534339.

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Keywords: C 646, supplier, C646, p300, CREB-binding, proteins, CBP, inhibitors, inhibits, histone, acetyltransferase, hat, kat, posttranslational, modifications, epigenetics, Tocris Bioscience, Histone Acetyltransferase Inhibitor products

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