IEM 1754 dihydrobromide
Cat. No. 4199
Chemical Name: N-(Tricyclo[220.127.116.11,7]dec-1-ylmeth
Biological ActivityVoltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluR2 subunit-lacking (Ca2+-permeable) receptors more potently than GluR2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265. PMID: 10694232.
Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655. PMID: 9457643.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses IEM 1754 dihydrobromide from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: IEM 1754 dihydrobromide, supplier, IEM1754, 2HBr, AMPA, receptor, blocker, blocks, AMPAR, voltage-dependent, Tocris Bioscience, AMPA Receptor Blocker products
Find multiple products by catalog number
New Products in this Area
NMDA receptor modulator; metabolite of Ketamine hydrochloride (Cat. No.3131)2S,6S-Hydroxynorketamine hydrochloride
Potent AMPA agonist; antidepressant2R,6R-Hydroxynorketamine hydrochloride
Potent AMPA agonist; lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; metabolite of Ketamine hydrochloride (Cat. No.3131).PEAQX tetrasodium salt
Potent NMDA receptor antagonist; NR2A selective
March 18 - 22, 2017
Little Rock, ARK, USA