Cat. No. 4196
Chemical Name: B-[3-[[4-[[3-[(4-Fluorophenyl)methy
Biological ActivitySelective autotaxin inhibitor (IC50 = 28 nM). Binds and inhibits autotaxin reversibly. Displays no activity against the proteasome, recombinant NPP1 or alkaline phosphatase. Inhibits ATX-mediated cell migration in an A2058 melanoma cell assay.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Albers et al (2010) Discovery and optimization of boronic acid based inhibitors of autotaxin. J.Med.Chem. 53 4958. PMID: 20536182.
Albers et al (2010) Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc.Natl.Acad.Sci.USA 107 7257. PMID: 20360563.
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Keywords: HA 130, supplier, HA130, autotaxin, inhibitors, reversible, reversibly, inhibits, selective, atx, npp2, lysophospholipases, d, lysopld, Tocris Bioscience, Autotaxin Inhibitor products