VPC 23019

Cat. No. 4195

VPC 23019 C17H29N2O5P [449173-19-7]

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Chemical Name: 2-Amino-N-(3-octylphenyl)-3-(phosphonooxy)-propanamaide

Biological Activity

Sphingosine-1-phosphate receptor antagonist; inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).

Technical Data

M.Wt:
372.4
Formula:
C17H29N2O5P
Solubility:
Soluble to 10 mM in Acidified DMSO (5% 1N HCl in DMSO) with gentle warming and to 50 mM in 2eq. NaOH
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
449173-19-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Aoki et al (2007) The suppressive effect of sphingosine-1-phosphate on monocyte-endothelium adhesion may be mediated by the rearrangement of the endothelial integrins α5β1 and αVβ3. J.Thromb.Haemost. 5 1292. PMID: 17403093.

Mihovilovic et al (2007) High-fat/cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. J.Lipid Res. 48 806. PMID: 17264352.

Davis et al (2005) Sphingosine-1-phosphate analogs as receptor antagonists. J.Biol.Chem. 280 9833. PMID: 15590668.

If you know of a relevant reference for VPC 23019 please let us know.

Citations are publications that use Tocris products. Selected citations for VPC 23019 include:

Willems et al (2016) Sphingosine-1-phosphate receptor inhibition prevents denervation-induced dendritic atrophy. Evid Based Complement Alternat Med 4 28. PMID: 27036416.

Wirrig et al (2016) Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells Biochemical Pharmacology 115 43. PMID: 27402345.

Miller et al (2008) Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells. Mol Cell Biol 28 4142. PMID: 18426913.

Do you know of a great paper that uses VPC 23019 from Tocris? If so please let us know.

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Keywords: VPC 23019, supplier, VPC23019, sphingosine-1-phosphate, s1p1, s1p3, antagonists, s1p, sphingolipids, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products

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