WY 45233 succinate

Cat. No. 4194

WY 45233 succinate C16H25NO2.C4H6O4 [448904-47-0]

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Alternative Name: Desvenlafaxine

Chemical Name: 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate

Biological Activity

Serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Inhibits [3H]5-HT and [3H]NE uptake (IC50 values are 47.3 and 531.3 nM). Salt form of the major active metabolite of venlafaxine (Cat. No. 2917).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 50 mM in water and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mason et al (2007) Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. J.Pharmacol.Exp.Ther. 323 720. PMID: 17673606.

Alfinito et al (2006) Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley rats. Brain Res. 1098 71. PMID: 16764833.

Deecher et al (2006) Desvenlafaxine succinate: a new serotonin and norepinephrine reuptake inhibitor. J.Pharmacol.Exp.Ther. 318 657. PMID: 16675639.

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