Cat. No. 4190
Chemical Name: 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-meth
Biological ActivitySelective, high affinity PPARα agonist (Ki values are 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Exhibits hypolipidemic activity in vivo.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kane et al (2009) Molecular characterization of novel and selective peroxisome proliferator-activated receptor α agonists with robust hypolipidemic activity in vivo. Mol.Pharmacol. 75 296. PMID: 18971326.
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Citations are publications that use Tocris products. Selected citations for CP 775146 include:
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. Hum Mol Genet 10 e0120295. PMID: 25811180.
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Keywords: CP 775146, supplier, pfizer, CP775146, pparalpha, ppara, pparα, peroxisome, proliferator-activated, receptors, agonists, selective, hypolipidemic, hypolipidaemic, Tocris Bioscience, PPARα Agonist products