SC 26196

Cat. No. 4189

SC 26196 C27H29N5 [218136-59-5]

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Chemical Name: α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

Biological Activity

Selective Δ6 desaturase inhibitor (IC50 = 0.2 μM in vitro). Displays selectivity over Δ5 and Δ9 desaturases (IC50 values are >200 μM in vitro). Exhibits anti-inflammatory properties in a mouse edema model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 25 mM in DMSO
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Zhang et al (2010) A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J.Biomol.Screen. 15 169. PMID: 20086206.

Hansen-Petrik et al (2002) Selective inhibition of delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 175 157. PMID: 11741743.

Obukowicz et al (1998) Novel, selective Δ6 or Δ5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J.Pharmacol.Exp.Ther. 287 157. PMID: 9765335.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SC 26196 include:

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. PLoS One 12 109. PMID: 26656090.

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Keywords: SC 26196, supplier, Pfizer, SC26196, desaturases, delta6, d6, Δ6, selective, inhibitors, inhibits, anti-inflammatory, fatty, acid, metabolism, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

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