Cat. No. 4187
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-p
Biological ActivityPotent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571. PMID: 11229774.
If you know of a relevant reference for UK 356618 please let us know.
Citations are publications that use Tocris products. Selected citations for UK 356618 include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382. PMID: 25365206.
Do you know of a great paper that uses UK 356618 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UK 356618, supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, matrix, metalloproteinase, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective high affinity MMP2 inhibitor(R)-MG 132
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitor
May 17 - 19, 2017