Cat. No. 4187
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-p
Biological ActivityPotent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571. PMID: 11229774.
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Citations are publications that use Tocris products. Selected citations for UK 356618 include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382. PMID: 25365206.
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Keywords: UK 356618, supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, matrix, metalloproteinase, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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