UK 356618

Cat. No. 4187

UK 356618 C34H43N3O4 [230961-08-7]

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Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine

Biological Activity

Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
557.72
Formula:
C34H43N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
230961-08-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571. PMID: 11229774.

If you know of a relevant reference for UK 356618 please let us know.

Citations are publications that use Tocris products. Selected citations for UK 356618 include:

Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382. PMID: 25365206.

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Keywords: UK 356618, supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, matrix, metalloproteinase, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

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