UK 5099

Cat. No. 4186

UK 5099 C18H12N2O2 [56396-35-1]

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Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid

Biological Activity

Inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925. PMID: 16766717.

Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607. PMID: 12887330.

Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479. PMID: 8526859.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for UK 5099 include:

Kaji et al (2015) SCFA transport in rat duodenum. Nat Chem Biol 308 G188. PMID: 25394661.

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Keywords: UK 5099, supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Tocris Bioscience, Monocarboxylate Transporter Inhibitor products

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