Cat. No. 4186
Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-
Biological ActivityInhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hinoi et al (2006) A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 70 925. PMID: 16766717.
Hildyard et al (2003) Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 374 607. PMID: 12887330.
Wiemer et al (1995) The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 312 479. PMID: 8526859.
If you know of a relevant reference for UK 5099 please let us know.
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Keywords: UK 5099, supplier, UK5099, inhibitor, transporters, mitochondrial, pyruvate, transport, inhibitors, MPT, inhibits, monocarboxylate, transporter, MCT, Tocris Bioscience, Monocarboxylate Transporter Inhibitor products
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