Cat. No. 4185
Alternative Names: PNU 101387, U 101387
Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benz
Biological ActivitySelective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Merchant et al (1996) Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J.Pharm.Exp.Ther. 279 1392.
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