Cat. No. 4185

Sonepiprazole C21H27N3O3S [170858-33-0]

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Alternative Names: PNU 101387, U 101387

Chemical Name: 4-[4-[2-[(1S)-3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]-benzenesulfonamide

Biological Activity

Selective, high affinity antagonist for the rat and human dopamine D4 receptor (Ki = 10 nM). Exhibits low affinity at other monoamine receptors (Ki > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

Soluble to 100 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Merchant et al (1996) Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist. J.Pharm.Exp.Ther. 279 1392.

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Keywords: Sonepiprazole, supplier, Sonepiprazole, selective, dopamine, antagonists, D4, receptors, dopaminergic, U101387, PNU101387, pfizer, Tocris Bioscience, D4 Receptor Antagonist products

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