Torcetrapib

Cat. No. 4184

Torcetrapib C26H25F9N2O4 [262352-17-0]

Price and Availability

For Torcetrapib pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester

Biological Activity

Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
600.47
Formula:
C26H25F9N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
262352-17-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459. PMID: 20051879.

Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465. PMID: 18536749.

If you know of a relevant reference for Torcetrapib please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Torcetrapib from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Torcetrapib, supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Tocris Bioscience, Other Transferase Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

New Products in this Area

GSK 343

Potent and selective SAM-competitive EZH2 inhibitor

BRD 4770

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable

Lys-CoA

Selective p300 inhibitor

UNC 2399

Biotinylated UNC 1999 (Cat.No. 4904)

PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

TP 064

Potent and selective PRMT 4 inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.