Torcetrapib

Cat. No. 4184

Torcetrapib C26H25F9N2O4 [262352-17-0]

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Chemical Name: (2R,4S)-4-[[[3,5-bis(Trifluoromethyl)phenyl]methyl](methoxycarbonyl)amino]-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylic acid ethyl ester

Biological Activity

Inhibitor of cholesteryl ester transfer protein (CETP). Also impairs endothelial function in vivo; induces hypertension and inhibits acetylcholine-induced vasodilation in rabbit central ear artery.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M.Wt:
600.47
Formula:
C26H25F9N2O4
Solubility:
Soluble to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
262352-17-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Connelly et al (2010) Torcetrapib produces endothelial dysfunction independent of cholesteryl ester transfer protein inhibition. J.Cardiovascular Pharmacol. 55 459. PMID: 20051879.

Forrest et al (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increasing circulating levels of aldosterone. Br.J.Pharmacol. 154 1465. PMID: 18536749.

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Keywords: Torcetrapib, supplier, hypercholesterolemia, inhibits, cholesteryl, ester, transferase, protein, CETP, impairs, endothelial, function, Tocris Bioscience, Other Transferase Inhibitor products

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