Aripiprazole

Cat. No. 5584

Aripiprazole C23H27Cl2N3O2 [129722-12-9]

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Chemical Name: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone

Biological Activity

High affinity dopamine D2 and 5-HT1A receptor partial agonist (Ki values are ~1.64 and 5.59 nM respectively). Also 5-HT2A antagonist (Ki = 8.7 nM). Suppresses morphine-induced emesis in vivo. Atypical antipsychotic.

Technical Data

M.Wt:
448.39
Formula:
C23H27Cl2N3O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
129722-12-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Shiokawa et al (2007) Usefulness of the dopamine system-stabilizer aripiprazole for reducing morphine-induced emesis. Eur.J.Pharmacol. 570 108. PMID: 17678644.

Davies et al (2004) Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 10 317. PMID: 15592581.

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Keywords: Aripiprazole, supplier, high, affinity, dopamine, D2, 5-ht1a, 5-ht2a, partial, agonists, antagonists, antipsychotic, Tocris Bioscience, D2 Receptor Agonist products

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