Ro 3306

Cat. No. 4181

Ro 3306 C18H13N3OS2 [872573-93-8]

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Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

Biological Activity

ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).

Technical Data

M.Wt:
351.45
Formula:
C18H13N3OS2
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
872573-93-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yu et al (2012) CDK1 regulates mediator of DNA damage checkpoint 1 during mitotic DNA damage. Cancer Res. 72 5448. PMID: 22962268.

Kojima et al (2009) The CDK1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 100 1128. PMID: 19385969.

Vassilev et al (2006) Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc.Natl.Acad.Sci. 103 10660.

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Citations are publications that use Tocris products. Selected citations for Ro 3306 include:

Shukla et al (2015) Plk1 relieves centriole block to reduplication by promoting daughter centriole maturation. Nat Commun 6 8077. PMID: 26293378.

Silva et al (2015) A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Mol Cell 14 1070. PMID: 25602147.

Goonesekere et al (2014) A meta analysis of pancreatic microarray datasets yields new targets as cancer genes and biomarkers. PLoS One 9 e93046. PMID: 24740004.

Rossi et al (2013) Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase. Am J Physiol Gastrointest Liver Physiol 49 1159. PMID: 23478441.

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Keywords: Ro 3306, supplier, Ro3306, inhibits, cdk1, cyclin-dependent, kinase, 1, inhibitors, cell, cycle, arrest, apoptotic, Tocris Bioscience, Cyclin-Dependent Protein Kinase Inhibitor products

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