Cat. No. 4180
Chemical Name: 2,3,3a,8b-Tetrahydro-2-hydroxy-1-(3
Biological ActivityPotent IP receptor agonist; analog of Epoprostenol (Cat. No. 2989). Potently inhibits ADP-induced platelet aggregation and P-selectin expression in vitro (pIC50 values are 8.26 and 8.56, respectively). Also increases vasodilation and reduces pulmonary hypertension in vivo. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Miyamoto et al (2003) Effects of TRA-418, a novel TP-receptor antagonist, and IP-receptor agonist, on human platelet activation and aggregation. Br.J.Pharmacol. 140 889. PMID: 14504133.
Saito et al (1995) Effects of beraprost sodium (a PGI2 derivative) on chronic hypoxic pulmonary hypertension in the rat. Nihon Kyobu Shikkan Gakkai Zasshi. 33 497. PMID: 7609334.
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Keywords: Beraprost sodium, supplier, Prostacyclin, IP, receptor, agonists, pulmonary, hypertension, vasodilation, platelet, aggregation, Tocris Bioscience, Prostanoid Receptor Agonist products
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