AMD 3465 hexahydrobromide

Cat. No. 4179

AMD 3465 hexahydrobromide C24H38N6.6HBr [185991-07-5]

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Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

Biological Activity

Potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.

Technical Data

Soluble to 50 mM in water and to 25 mM in DMSO
>97 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Bodart et al (2009) Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4. Biochem.Pharmacol. 78 993. PMID: 19540208.

Rosenkilde et al (2007) Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J.Biol.Chem. 282 27354. PMID: 17599916.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:

Lourenco et al (2015) Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors. J Immunol 194 3463. PMID: 25712213.

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Keywords: AMD 3465 hexahydrobromide, supplier, AMD3465, CXCR4, receptor, antagonist, chemokine, receptor, chemokines, antagonists, Tocris Bioscience, Chemokine CXC Receptor Antagonist products

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