AS 1269574

Cat. No. 4177

AS 1269574 C13H14BrN3O [330981-72-1]

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Chemical Name: 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol

Biological Activity

GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Orally available.

Technical Data

M.Wt:
308.17
Formula:
C13H14BrN3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
330981-72-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Chepurny et al (2013) Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag. Mol.Endocrinol. 27 1267. PMID: 23798572.

Yoshida et al (2010) Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo glucose-stimulated insulin secretion. Biochem.Biophys.Res.Commun. 400 437. PMID: 20804735.

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Keywords: AS 1269574, supplier, AS1269574, Supplier, GPR119, agonist, glucose-dependent, insulin, Tocris Bioscience, GPR119 Agonist products

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