Cat. No. 1509
Alternative Name: (E)-2,3',4,5'-tetramethoxystilbene
Chemical Name: 1-[2,(3,5-Dimethoxyphenyl)ethenyl]-
Biological ActivityPotent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kim et al (2002) Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J.Med.Chem. 45 160. PMID: 11754588.
Chun et al (2001) A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Res. 61 8164. PMID: 11719446.
Nam et al (2001) Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch.Pharm.Res. 24 441. PMID: 11693548.
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Keywords: TMS, supplier, Cytochrome, P450, 1B1, inhibitors, inhibits, CYP, Tocris Bioscience, Cytochrome P450 Inhibitor products
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