Ozagrel hydrochloride

Cat. No. 1510

Ozagrel hydrochloride C13H12N2O2.HCl [74003-18-2]

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Alternative Name: OKY 046

Chemical Name: (2E)-3-[4-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride

Biological Activity

Potent and selective inhibitor of thromboxane (TXA2) synthetase (IC50 = 4 nM). Does not inhibit prostacyclin (PGI2) synthetase, cyclooxygenase or PGE2 isomerase (IC50 > 1 mM). Inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo.

Technical Data

M.Wt:
264.71
Formula:
C13H12N2O2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
74003-18-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Shinagawa et al (2000) Participation of thromboxane A2 in the cough response in guinea-pigs: antitussive effect of ozagrel. Br.J.Pharmacol. 131 266. PMID: 10991919.

Hiraku et al (1986) Pharmacological studies on the TXA2 synthetase inhibitor (E)-3-[p-(1H-imidazol-1ylmethyl)phenyl]-2-propenoic acid (OKY-046). Jpn.J.Pharmacol. 41 393. PMID: 3093741.

Naito et al (1983) Effects of thromboxane synthetase inhibitors on aggregation of rabbit platelets. Eur.J.Pharmacol. 91 41. PMID: 6413227.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ozagrel hydrochloride include:

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228. PMID: 19096033.

Rancillac et al (2006) Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum. Proc Natl Acad Sci U S A 26 6997. PMID: 16807329.

Do you know of a great paper that uses Ozagrel hydrochloride from Tocris? If so please let us know.

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Keywords: Ozagrel hydrochloride, supplier, Selective, thromboxane, A2, synthetase, inhibitors, inhibits, Thromboxane, TP, Prostanoid, Synthases, Synthetases, prostaglandins, prostacyclins, eicosanoids, OKY046, Tocris Bioscience, Prostanoid Receptor products

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