Pramipexole dihydrochloride

Cat. No. 4174

Pramipexole dihydrochloride C10H17N3S.2HCl [104632-25-9]

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Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride

Biological Activity

Dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Mierau et al (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur.J.Pharmacol. 290 29. PMID: 7664822.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. J Exp Bot 11 2057. PMID: 26649942.

Bonito-Oliva et al (2014) A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. Front Behav Neurosci 8 290. PMID: 25221486.

Do you know of a great paper that uses Pramipexole dihydrochloride from Tocris? If so please let us know.

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Keywords: Pramipexole dihydrochloride, supplier, dopamine, D3, agonists, Parkinsons, Disease, antiparkinson, parkinson's, dopaminergic, Tocris Bioscience, D3 Receptor Agonist products

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