Cat. No. 4174
Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(p
Biological ActivityDopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Mierau et al (1995) Pramipexole binding and activation of cloned and expressed dopamine D2, D3 and D4 receptors. Eur.J.Pharmacol. 290 29. PMID: 7664822.
If you know of a relevant reference for Pramipexole dihydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:
Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. J Exp Bot 11 2057. PMID: 26649942.
Bonito-Oliva et al (2014) A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions. Front Behav Neurosci 8 290. PMID: 25221486.
Do you know of a great paper that uses Pramipexole dihydrochloride from Tocris? If so please let us know.
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Keywords: Pramipexole dihydrochloride, supplier, dopamine, D3, agonists, Parkinsons, Disease, antiparkinson, parkinson's, dopaminergic, Tocris Bioscience, D3 Receptor Agonist products
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