ML 145

Cat. No. 4172

ML 145 C24H22N2O5S2 [1164500-72-4]

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Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid

Biological Activity

Selective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.

Technical Data

M.Wt:
482.57
Formula:
C24H22N2O5S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1164500-72-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683. PMID: 22967846.

Heynen-Genel et al (2010) Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program NBK5070.

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Keywords: ML 145, supplier, ML145, Supplier, orphan, receptor, antagonist, antagonists, GPR35, Tocris Bioscience, GPR35 Antagonist products

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