Cat. No. 4172
Chemical Name: 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl
Biological ActivitySelective antagonist for the GPR35 orphan receptor GPCR (IC50 = 20.1 nM). Over 1000-fold more selective for GPR35 compared to GPR55 antagonists.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Jenkins et al (2012) Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J.Pharmacol.Exp.Ther. 343 683. PMID: 22967846.
Heynen-Genel et al (2010) Antagonists for the orphan receptor GPR35. Probe Reports from the Molecular Libraries Program NBK5070.
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Keywords: ML 145, supplier, ML145, Supplier, orphan, receptor, antagonist, antagonists, GPR35, Tocris Bioscience, GPR35 Antagonist products
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