KS 176

Cat. No. 4169

KS 176 C22H19N3O5 [1253452-78-6]

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Chemical Name: N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide

Biological Activity

Selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

Technical Data

M.Wt:
405.4
Formula:
C22H19N3O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1253452-78-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pick et al (2010) Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 5 1498. PMID: 20632361.

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Keywords: KS 176, supplier, KS176, selective, inhibitors, inhibits, breast, cancer, resistance, protein, BCRP, multidrug, transporter, ATP-binding, cassettes, Tocris Bioscience, Multidrug Transporter Inhibitor products

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