Cat. No. 4168
Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophen
Biological ActivitySelective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Miao et al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci. 107 2012.
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Keywords: PIT 1, supplier, PIT1, Supplier, Akt, signaling, inhibitors, inhibits, blocks, PH-PIP3, pleckstrin, homology, PITenins, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products