KW 3902

Cat. No. 4167

KW 3902 C20H28N4O2 [136199-02-5]

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Alternative Name: Rolofylline

Chemical Name: 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione

Biological Activity

Selective adenosine A1 receptor antagonist; displays 890-fold selectivity for rat A1 receptors over A2A receptors (Ki values are 0.19 and 170 nM respectively). Displays no effect on recombinant rat A3 receptors expressed on CHO cells at concentrations up to 10 μM. Exhibits diuretic and renal protective effects in rats.

Technical Data

M.Wt:
356.46
Formula:
C20H28N4O2
Solubility:
Soluble to 50 mM in DMSO and to 25 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
136199-02-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Nishiyama et al (1999) Adenosine A1 receptor antagonist KW-3902 prevents hypoxia-induced renal vasoconstriction. J.Pharmacol.Exp.Ther. 291 988. PMID: 10565815.

Nonaka et al (1996) KW-3902, a selective high affinity antagonist for adenosine A1 receptors. Br.J.Pharmacol. 117 1645. PMID: 8732272.

Shimada et al (1992) 8-polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors. J.Med.Chem. 35 924. PMID: 1548682.

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Keywords: KW 3902, supplier, adenosine, a1, antagonists, selective, KW3902, Tocris Bioscience, Adenosine A1 Receptor Antagonist products

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