Cat. No. 4165
Alternative Name: UK 369003
Chemical Name: 5-[2-Ethoxy-5-[(4-ethyl-1-piperazin
Biological ActivityPotent PDE5 inhibitor (IC50 = 1.23 nM). Shows >100-fold selectivity for PDE5 over PDE6. Orally bioavailable.
Licensing InformationSold for research purposes under agreement from Pfizer Inc.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Rawson et al (2012) The discovery of UK-369003, a novel PDE5 inhibitor with the potential for oral bioavailability and dose-proportional pharmacokinetics. Bioorg.Med.Chem. 20 498. PMID: 22100260.
Hashim and Abrams (2010) Emerging drugs for the treatment of benign prostatic obstruction. Exp.Opin.Invest.Drugs 15 159. PMID: 20446824.
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Keywords: Gisadenafil besylate, supplier, pfizer, phosphodiesterases, inhibitors, inhibits, PDE5, UK369003, Tocris Bioscience, Phosphodiesterase Inhibitor products
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