FR 122047 hydrochloride

Cat. No. 1507

FR 122047 hydrochloride C23H25N3O3S.HCl [130717-51-0]

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Chemical Name: 1-[[4,5-bis(4-Methoxyphenyl)-2-thiazolyl]carbonyl]-4-methylpiperazine hydrochloride

Biological Activity

Selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.028 and 65 μM for COX-1 and COX-2 respectively). Antiplatelet, analgesic and anti-inflammatory following oral administration in vivo.

Technical Data

M.Wt:
459.99
Formula:
C23H25N3O3S.HCl
Solubility:
Soluble to 10 mM in water
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
130717-51-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Ochi and Goto (2002) Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br.J.Pharmacol. 135 782. PMID: 11834626.

Ochi et al (2000) The analgesic effect profile of FR122047, a selective cyclo-oxygenase-1 inhibitor, in chemical nociceptive models. Eur.J.Pharmacol. 391 49. PMID: 10720634.

Tanaka et al (1994) Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J.Med.Chem. 37 1189. PMID: 8164261.

Dohi et al (1993) The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur.J.Pharmacol. 243 179. PMID: 8276067.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for FR 122047 hydrochloride include:

Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10. PMID: 21955547.

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Keywords: FR 122047 hydrochloride, supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, FR122047, hydrochloride, Tocris Bioscience, Cyclooxygenase Inhibitor products

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