Dynole 34-2

Cat. No. 4222

Dynole 34-2 C25H36N4O [1128165-88-7]

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Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide

Biological Activity

Dynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).

Technical Data

Soluble to 100 mM in DMSO and to 50 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094. PMID: 20426422.

Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762. PMID: 19459681.

If you know of a relevant reference for Dynole 34-2 please let us know.

Citations are publications that use Tocris products. Selected citations for Dynole 34-2 include:

Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325. PMID: 25406314.

Do you know of a great paper that uses Dynole 34-2 from Tocris? If so please let us know.

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Keywords: Dynole 34-2, supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, Tocris Bioscience, GTPase Inhibitor products

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