Cat. No. 4222
Chemical Name: 2-Cyano-3-[1-[3-(dimethylamino)prop
Biological ActivityDynamin I inhibitor (IC50 = 1.3 μM). Inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Hill et al (2010) Iminochromene inhibitors of dynamins I and II GTPase activity and endocytosis. J.Med.Chem. 53 4094. PMID: 20426422.
Hill et al (2009) Inhibition of dynamin mediated endocytosis by the dynoles - synthesis and functional activity of a family of indoles. J.Med.Chem. 52 3762. PMID: 19459681.
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Citations are publications that use Tocris products. Selected citations for Dynole 34-2 include:
Han et al (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Am J Physiol Cell Physiol 290 325. PMID: 25406314.
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Keywords: Dynole 34-2, supplier, dynamin, I, inhibitors, inhibits, gtpases, rme, receptor-mediated, endocytosis, Tocris Bioscience, GTPase Inhibitor products