Cat. No. 4163
Chemical Name: N-(Cyclohexylmethyl)-2-[(5-[(phenyl
Biological ActivityNMDA receptor antagonist, selective for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
McKay et al (2012) Direct pharmacological monitoring of the developmental switch in NMDAR subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. Br.J.Pharmacol. 166 924. PMID: 22022974.
Bettini et al (2010) Identification and characterization of novel NMDA receptor antagonists selective for NR2A- over NR2B-containing receptors. J.Pharmacol.Exp.Ther. 335 644. PMID: 20810618.
If you know of a relevant reference for TCN 213 please let us know.
Citations are publications that use Tocris products. Selected citations for TCN 213 include:
Izumi and Zorumski (2015) Sensitivity of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials and synaptic plasticity to TCN 201 and TCN 213 in rat hippocampal slices. Int J Mol Sci 352 267. PMID: 25413830.
Prickett et al (2014) Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation. J Invest Dermatol 134 2390. PMID: 24739903.
Do you know of a great paper that uses TCN 213 from Tocris? If so please let us know.
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Keywords: TCN 213, supplier, TCN213, selective, NMDA, receptor, antagonist, NR1/NR2A, NR2A-containing, NR2B, Tocris Bioscience, NMDA Receptor Antagonist products