Cat. No. 4160
Alternative Name: Maxacalcitol
Chemical Name: (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(
Biological ActivityNon-calcemic vitamin D3 (Cat. No. 4156) analog and VDR ligand. Suppresses parathyroid hormone (PTH) mRNA expression in vitro and in vivo. Exhibits similar effects to calcitriol (Cat. No. 2551) in osteoblast-like cells. Inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Barroga et al (2000) Inhibitory effects of 22-oxa-calcitriol and all-trans retinoic acid on the growth of a canine osteosarcoma derived cell-line in vivo and its pulmonary metastasis in vivo. Res.Vet.Sci. 68 79. PMID: 10684763.
Monier-Faugere et al (1999) 22-Oxacalcitriol suppresses secondary hyperparathyroidism without inducing low bone turnover in dogs with renal failure. Kidney Int. 55 821. PMID: 10027919.
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Keywords: 22-Oxacalcitriol, supplier, 22-Oxacalcitriol, OCT, vitamin, D, analogue, analog, non-calcemic, VDR, Tocris Bioscience, Vitamin D Receptor products
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