Phorbol 12,13-dibutyrate

Cat. No. 4153

Phorbol 12,13-dibutyrate C28H40O8 [37558-16-0]

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Alternative Name: PDBu

Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1a,1b,4,4a,5,7a,7b,8,9,9a-Decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa[3,4]benz[1,2-e]azulen-9,9a-diyl butanoic acid ester

Biological Activity

Protein kinase C activator. Induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Activity does not alter intracellular Ca2+ concentration. Also inhibits the activity of Na+,K+ ATPase in OK cells.

Technical Data

M.Wt:
504.61
Formula:
C28H40O8
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
37558-16-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Sakai et al (2010) Augmented PDBu-mediated contaction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness. J.Smooth Muscle Res. 46 259. PMID: 21187674.

Hori et al (1999) Presynaptic mechanism for phorphol ester-induced synaptic potentiation. J.Neurosci. 19 7262. PMID: 10460232.

Middleton et al (1993) Heterogeneity of protein kinase C-mediated rapid regulation of Na/K-ATPase in kidney epithelial cells. J.Biol.Chem. 268 15958. PMID: 8393456.

If you know of a relevant reference for Phorbol 12,13-dibutyrate please let us know.

Citations are publications that use Tocris products. Selected citations for Phorbol 12,13-dibutyrate include:

Nostro et al (2015) Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. J Cell Biol 4 591. PMID: 25843049.

Do you know of a great paper that uses Phorbol 12,13-dibutyrate from Tocris? If so please let us know.

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Keywords: Phorbol 12,13-dibutyrate, supplier, PDBu, protein, kinases, c, pkc, activators, phorbol, esters, Tocris Bioscience, Protein Kinase C Activator products

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