Cat. No. 4152
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)c
Biological ActivityPotent cyclophilin A inhibitor (IC50 = 1.52 nM). Approximately 27 times more potent than cyclosporin A (Cat. No. 1101).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ni et al (2009) Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach. J.Med.Chem. 52 5295. PMID: 19691347.
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Citations are publications that use Tocris products. Selected citations for TMN 355 include:
Ahmed-Belkacem et al (2016) Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities. Nature Communications 7 12777. PMID: 27652979.
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Keywords: TMN 355, supplier, TMN355, cyclophilin, a, cypA, immunosuppressants, immunophilins, ppiase, inhibitors, inhibits, Tocris Bioscience, Miscellaneous Compound products
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