Azidothymidine

Cat. No. 4150

Azidothymidine C10H13N5O4 [30516-87-1]

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Chemical Name: 3'-Azido-3'-deoxythymidine

Biological Activity

Selective reverse transcriptase inhibitor. Exhibits 100-fold selectivity for HIV reverse transcriptase over DNA polymerase α. Suppresses HIV-1 replication and enhances cell viability in HIV-1 infected T cells. Attenuates growth of multiple myeloma (MM) cells in vitro and reduces growth of MM tumor xenografts in mice. Orally bioavailable and brain penetrant. Antiretroviral agent. Also decreases CRISPR-mediated homology directed repair (HDR) efficiency.

Licensing Information

Sold for research purposes under agreement from Viiv.

Technical Data

M.Wt:
267.24
Formula:
C10H13N5O4
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
30516-87-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142. PMID: 25658371.

Pereira et al (2013) Azidothymidine is effective against human multiple myeloma: a new use for an old drug? Anticancer Agents Med.Chem. 13 186. PMID: 22931421.

Broder (2010) The development of antiretroviral therapy and its impact on the HIV-1/AIDS pandemic. Antiviral Res. 85 1. PMID: 20018391.

Furman et al (1986) Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase. Proc.Natl.Acad.Sci.U.S.A. 83 8333. PMID: 2430286.

Mitsuya et al (1985) 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro. Proc.Natl.Acad.Sci.U.S.A. 82 7096. PMID: 2413459.

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Keywords: Azidothymidine, supplier, selective, reverse, transcriptase, inhibitors, inhibits, antiretroviral, HIV, human, immunodeficiency, virus, dna, rna, polymerase, CRISPR, Cas9, HDR, homology, directed, repair, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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