Delavirdine mesylate

Cat. No. 4149

Delavirdine mesylate C22H28N6O3S.CH3SO3H [147221-93-0]

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Alternative Name: U 90152

Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyridinyl]-4-[[5-[(methylsulfonyl)amino]-1H-indol-2-yl]carbonyl]-piperazine monomethanesulfonate

Biological Activity

Non-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.

Licensing Information

Sold for research purposes under agreement from Viiv.

Technical Data

M.Wt:
552.67
Formula:
C22H28N6O3S.CH3SO3H
Solubility:
Soluble to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
147221-93-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha. J.Infect.Dis. 171 61. PMID: 7528253.

Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127. PMID: 7685995.

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Keywords: Delavirdine mesylate, supplier, reverse, transcriptase, inhibitors, inhibits, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products

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