Cat. No. 4149
Alternative Name: U 90152
Chemical Name: 1-[3-[(1-Methylethyl)amino]-2-pyrid
Biological ActivityNon-nucleoside reverse transcriptase inhibitor (NNRTI). Selectively inhibits HIV-1 reverse transcriptase (RNA-dependent DNA polymerase) over other cellular polymerases (IC50 values are 0.26, 440 and >550 μM for HIV-1 reverse transcriptase, DNA polymerase α and DNA polymerase δ). Prevents HIV-1 spread in vivo and blocks viral replication in peripheral blood lymphocytes. Orally active.
Licensing InformationSold for research purposes under agreement from Viiv.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pagano and Chong (1995) In vitro inhibition of human immunodeficiency virus type 1 by a combination of delavirdine (U-90152) with protease inhibitor U-75875 or interferon-alpha. J.Infect.Dis. 171 61. PMID: 7528253.
Dueweke et al (1993) U-90152, a potent inhibitor of human immunodeficiency virus type 1 replication. Antimicrob.Agents Chemother. 37 1127. PMID: 7685995.
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Keywords: Delavirdine mesylate, supplier, reverse, transcriptase, inhibitors, inhibits, polymerases, RNA/DNA, antivirals, antiretrovirals, HIV, non-nucleoside, NNRTI, HIV-1, U90152, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products
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