Cat. No. 4148
Chemical Name: (1S,4R)-4-[2-Amino-6-(cyclopropylam
Biological ActivityCompetitive reverse transcriptase inhibitor; inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent.
Licensing InformationSold for research purposes under agreement from Viiv.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Charneira et al (2012) N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo. Br.J.Pharmacol. 167 1353. PMID: 22725138.
Harrigan et al (2000) Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J.Infect.Dis. 181 912. PMID: 10720512.
Daluge et al (1997) 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother. 41 1082. PMID: 9145874.
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Keywords: Abacavir hemisulfate, supplier, competitive, guanosine, analog, reverse, transcriptase, inhibitors, inhibits, HIV, replication, orally, active, brain, penetrant, antiretroviral, agents, Tocris Bioscience, RNA/DNA Polymerase Inhibitor products
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