PK 44 phosphate

Cat. No. 4145

PK 44 phosphate C17H16F5N7O.H3PO4 [1017682-66-4]

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Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate

Biological Activity

Potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Technical Data

M.Wt:
527.34
Formula:
C17H16F5N7O.H3PO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1017682-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52.

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Keywords: PK 44 phosphate, supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, PK44, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products

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