PK 44 phosphate

Cat. No. 4145

PK 44 phosphate C17H16F5N7O.H3PO4 [1017682-66-4]

Price and Availability

For PK 44 phosphate pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate

Biological Activity

Potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Improves glucose tolerance in a mouse oral glucose tolerance assay.

Technical Data

M.Wt:
527.34
Formula:
C17H16F5N7O.H3PO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1017682-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tozer et al (2010) Indole- and indazole-based inhibitors of dipeptidyl peptidase IV for the treatment of type 2 diabetes. 32nd Annual National Medicinal Chemistry Symposium Poster 52.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses PK 44 phosphate from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: PK 44 phosphate, supplier, dipeptidyl, peptidase, IV, DPP-IV, potent, selective, inhibitors, inhibits, PK44, Tocris Bioscience, Dipeptidyl Peptidase IV Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

(R)-MG 132

Potent 20S proteasome inhibitor

Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Acein

High affinity angiotensin-converting enzyme (ACE) ligand

TMI 1

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.