LY 2087101

Cat. No. 4141

LY 2087101 C15H11FN2OS2 [913186-74-0]

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Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone

Biological Activity

Allosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 105 14686.

Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108. PMID: 16738207.

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Keywords: LY 2087101, supplier, allosteric, potentiators, modulators, nicotinic, acetylcholine, receptors, nAChRs, alpha7, α7, a7, LY2087101, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products

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