Cat. No. 4141
Chemical Name: [2-[(4-Fluorophenyl)amino]-4-methyl
Biological ActivityAllosteric potentiator of α7, α4β2 and α4β4 nAChRs; displays selectivity against α3β4 nAChRs. Thought to potentiate agonist-evoked α7 responses by binding within the nAChR transmembrane region.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Young et al (2008) Potentiation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc.Natl.Acad.Sci. 105 14686.
Broad et al (2006) Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J.Pharmacol.Exp.Ther. 318 1108. PMID: 16738207.
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Keywords: LY 2087101, supplier, allosteric, potentiators, modulators, nicotinic, acetylcholine, receptors, nAChRs, alpha7, α7, a7, LY2087101, Tocris Bioscience, Nicotinic (α7) Receptor Modulator products
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