EB 47

Cat. No. 4140

EB 47 C24H27N9O6.2HCl [1190332-25-2]

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Chemical Name: 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride

Biological Activity

Potent inhibitor of PARP-1 (IC50 = 45 nM). Reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model.

Technical Data

M.Wt:
610.45
Formula:
C24H27N9O6.2HCl
Solubility:
Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1190332-25-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ferraris et al (2010) Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic. J.Med.Chem. 53 4561. PMID: 20364863.

Gaymes et al (2009) Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes. Haematologica 94 638. PMID: 19407318.

Jagtap et al (2004) The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1). Bioorg.Med.Chem.Lett. 14 81. PMID: 14684303.

If you know of a relevant reference for EB 47 please let us know.

Citations are publications that use Tocris products. Selected citations for EB 47 include:

Rom et al (2016) PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier Journal of Neuroinflammation 13 254. PMID: 27677851.

Rom et al (2015) Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. Front Microbiol 35 28. PMID: 25248836.

Rom et al (2015) The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. Dev Biol 6 878. PMID: 26379653.

Do you know of a great paper that uses EB 47 from Tocris? If so please let us know.

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Keywords: EB 47, supplier, EB47, PARP-1, poly(ADP-ribose), polymerase-1, inhibitors, inhibits, PARP1, Tocris Bioscience, Poly(ADP-Ribose) Polymerase Inhibitor products

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