Cat. No. 4138
Chemical Name: N-[2-[(4-Hydroxyphenyl)amino]-3-pyr
Biological ActivityAntimitotic agent, inhibits microtubule polymerization. Binds to β-tubulin on the colchine site; blocks cell cycle at G2M phase and induces apoptosis. Exhibits antitumor activity. Also displays activity in cell lines resistant to vincristine, doxorubicin and cisplatin. Orally bioavailable.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Hande et al (2006) The pharmacokinetics and safety of ABT-751, a novel, orally bioavailable sulfonamide antimitotic agent: results of a phase 1 study. Clin.Cancer Res. 12 2834. PMID: 16675578.
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Keywords: ABT 751, supplier, ABT751, microtubule, antitumor, antimitotic, beta, tubulin, b-tubulin, blocks, cell, cycle, G2M, proapoptotic, Tocris Bioscience, Microtubule products