Hygromycin B

Cat. No. 4137

Hygromycin B C20H37N3O13 [31282-04-9]

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Chemical Name: O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine

Biological Activity

Aminoglycoside antibiotic. Active against both prokaryotic and eukaryotic cells. Inhibits protein synthesis by binding to the 30S subunit and inhibiting the ribosomal translocation step of elongation.

Technical Data

M.Wt:
527.52
Formula:
C20H37N3O13
Solubility:
Soluble to 100 mM in water
Purity:
>90 %
Storage:
Store at +4°C
CAS No:
31282-04-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Ganoza and Kiel (2001) A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes. Antimicrob.Agents Chemother. 45 2813. PMID: 11557474.

Brodersen et al (2000) The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103 1143. PMID: 11163189.

Blochlinger and Diggelmann (1984) Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eukaryotic cells. Mol.Cell.Biol. 4 2929. PMID: 6098829.

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Keywords: Hygromycin B, supplier, hygromycinB, aminoglycoside, antibiotics, inhibits, protein, synthesis, ribosomal, translocation, ribosome, 30S, eukaryotic, prokaryotic, cells, Tocris Bioscience, Antibiotic products

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