Cat. No. 4136
Biological ActivityNR2B-selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing N2RB, but not NR2A, subunits (IC50 ~300 nM). Exhibits neuroprotective properties in vivo and in vitro.
(Modifications: X = Gla, Asn-17 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bush et al (2000) Selective antagonism of nigral neuropeptide responses to methamphetamine by conantokin G, a naturally occurring conopeptide. Eur.J.Pharmacol. 387 55. PMID: 10633160.
Donevan and McCabe (2000) Conantokin G is an NR2B-selective competitive antagonist of N-methyl-D-aspartate receptors. Mol.Pharmacol. 58 614. PMID: 10953056.
Williams et al (2000) Neuroprotective efficacy and therapeutic window of the high-affinity N-methyl-D-aspartate antagonist conantokin-G: in vitro (primary cerebellar neurons) and in vivo (rat model of transient focal brain ischemia) studies. J.Pharmacol.Exp.Ther. 294 378. PMID: 10871336.
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Keywords: Conantokin G, supplier, neuroprotective, NMDA, receptors, antagonists, NR2B, selective, venoms, Tocris Bioscience, NMDA Receptor Antagonist products