G418 disulfate salt

Cat. No. 4131

G418 disulfate salt C20H40N4O10.2H2SO4 [108321-42-2]

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Biological Activity

Aminoglycosidic antibiotic. Inhibits protein synthesis in both prokaryotic and eukaryotic cells. Used for selection of eukaryotic cells transfected with the neo gene.

Technical Data

Soluble to 75 mM in water
Store at +4°C


Other Information

  • This product has been cell culture tested

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Burke and Mogg (1985) Suppression of a nonsense mutation in mammalian cells in vivo by the aminoglycoside antibiotics G-418 and paromomycin. Nucleic Acids Res. 13 6265. PMID: 2995924.

Bar-Nun et al (1983) G-418, an elongation inhibitor of 80 S ribosomes. Biochim.Biophys.Acta. 741 123. PMID: 6193810.

Wagman et al (1974) Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation and preliminary characterization. Antimicrob.Agents Chemother. 6 144. PMID: 15828184.

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Keywords: G418 disulfate salt, supplier, antibiotics, neomycin, resistance, cell, culture, aminoglycoside, inhibitors, inhibits, protein, synthesis, eukaryotes, eukaryotic, prokaryotes, prokaryotic, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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