KN 92

Cat. No. 4130

KN 92 C24H25ClN2O3S.H3PO4 [1135280-28-2]

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Chemical Name: 2-[N-(4'-Methoxybenzenesulfonyl)]amino-N-(4'-chlorophenyl)-2-propenyl-N-methylbenzylamine phosphate

Biological Activity

Inactive analog of the CaM kinase II inhibitor KN 93 (Cat. No. 1278). Potassium channel (Kv1.2, 1.4, 1.5, 2.1, 3.2 and hERG) blocker in vitro.

Technical Data

M.Wt:
554.98
Formula:
C24H25ClN2O3S.H3PO4
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1135280-28-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Rezazadeh et al (2005) KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels. J.Pharmacol.Exp.Ther. 317 292. PMID: 16368898.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for KN 92 include:

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. Oncotarget 8 e66404. PMID: 23799098.

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Keywords: KN 92, supplier, potassium, K+, blockers, Kv, channels, inactive, analog, KN93, KN92, calcium, binding, protein, modulators, voltage-gated, hERG, Human, Ether-A-Go-Go, Gene, voltage-dependent, CaM, Kinase, II, kinases, Calmodulin-Activated, calmodulin-dependent, Ca2+, Binding, modulators, Tocris Bioscience, Calcium Binding Protein Modulator products

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