Cat. No. 4126
Chemical Name: 4-[6-[4-(1-Methylethoxy)phenyl]pyra
Biological ActivitySelective inhibitor of the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Exhibits no detectable inhibition of AMPK, ALK5, KDR (VEGFR-2) or PDGFRβ receptors. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB 431542 (Cat. No. 1614).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Neely et al (2012) DMH1, a highly selective small molecule BMP inhibitor, promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction. ACS Chem.Neurosci. 3 482. PMID: 22860217.
Bowman and Zon (2010) Swimming into the future of drug discovery: in vivo chemical screens in zebrafish. ACS Chem.Biol. 5 159. PMID: 20166761.
Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245. PMID: 20020776.
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Citations are publications that use Tocris products. Selected citations for DMH-1 include:
Lu et al (2016) Generation of serotonin neurons from human pluripotent stem cells. Nat Biotechnol 34 89. PMID: 26655496.
Mou et al (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells Cell Stem Cell 19 217. PMID: 27320041.
Du et al (2015) Generation and expansion of highly pure motor neuron progenitors from human pluripotent stem cells. Nat.Commun. 6 6626. PMID: 25806427.
Martínez et al (2015) The BMP Pathway Participates in Human Naive CD4+ T Cell Activation and Homeostasis. Cell 10 e0131453. PMID: 26110906.
McDonald et al (2015) Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes. Arthritis Res Ther 160 105. PMID: 25579684.
Varas et al (2015) Blockade of bone morphogenetic protein signaling potentiates the pro-inflammatory phenotype induced by interleukin-17 and tumor necrosis factor-α combination in rheumatoid synoviocytes. Lab Chip 17 192. PMID: 26215036.
Li et al (2013) Flow-based pipeline for systematic modulation and analysis of 3D tumor microenvironments. J Biol Chem 13 1969. PMID: 23563587.
Liu et al (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc 8 1670. PMID: 23928500.
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Keywords: DMH-1, supplier, selective, activin, receptors, alk2, acvr1, bmp, type, I, bone, morphogenic, morphogenetic, protein, Tocris Bioscience, BMP and Other Activin Receptor Inhibitor products
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December 13 - 15, 2016