Cat. No. 4124
Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-etho
Biological ActivitySelective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518. PMID: 11906293.
Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13. PMID: 11594239.
Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704. PMID: 11095972.
Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907.
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Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:
Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481. PMID: 25759824.
Thakran et al (2015) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177. PMID: 25525174.
Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283. PMID: 24812009.
Do you know of a great paper that uses Pioglitazone hydrochloride from Tocris? If so please let us know.
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Keywords: Pioglitazone hydrochloride, supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, Tocris Bioscience, PPARγ Agonist products