Pioglitazone hydrochloride

Cat. No. 4124

Pioglitazone hydrochloride C19H20N2O3S.HCl [112529-15-4]

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Chemical Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)-ethoxy]phenyl]methyl]-2,4-thiazolidinedione hydrochloride

Biological Activity

Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity.

Technical Data

Soluble to 25 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Momose et al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518. PMID: 11906293.

Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13. PMID: 11594239.

Sakamoto et al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704. PMID: 11095972.

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907.

If you know of a relevant reference for Pioglitazone hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Pioglitazone hydrochloride include:

Byrne et al (2015) Characterisation of pain responses in the high fat diet/streptozotocin model of diabetes and the analgesic effects of antidiabetic treatments. J Diabetes Res 2015 752481. PMID: 25759824.

Thakran et al (2015) Pioglitazone restores IGFBP-3 levels through DNA PK in retinal endothelial cells cultured in hyperglycemic conditions. PLoS One 56 177. PMID: 25525174.

Wahlang et al (2014) Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. Toxicol Sci 140 283. PMID: 24812009.

Do you know of a great paper that uses Pioglitazone hydrochloride from Tocris? If so please let us know.

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Keywords: Pioglitazone hydrochloride, supplier, PPARg, PPARgamma, PPARγ, peroxisome, proliferator, activated, receptors, nuclear, agonists, antidiabetic, agents, Tocris Bioscience, PPARγ Agonist products

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