C3bot (154-182)

Cat. No. 4123

C3bot (154-182) Val-Ala-Lys-Gly-Ser-Lys-Ala-Gly-Tyr-Ile-Asp-Pro-Ile-Ser-Ala-Phe-Ala-Gly-Gln-Leu-Glu-Met-Leu-Leu-Pro-Arg-His-Ser-Thr

Price and Availability

For C3bot (154-182) pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.

Technical Data

M.Wt:
3058.54
Formula:
C137H221N37O40S
Sequence:
VAKGSKAGYIDPISAFAGQLEMLLPRHST
Solubility:
Soluble to 5 mg/ml in water
Storage:
Store at -20°C
CAS No:
1246280-79-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247.

Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652.

Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115. PMID: 19047066.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses C3bot (154-182) from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: C3bot (154-182), supplier, clostridium, clostridial, C3, protein, neurotrophic, axon, dendrite, outgrowth, transferase-deficient, peptide, fragment, spinal, cord, injury, injuries, c3, bot154-182, Tocris Bioscience, Neuronal Metabolism products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

divider line

New Products in this Area

Pladienolide B

mRNA splicing inhibitor; antitumor

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.