Cat. No. 4123
Biological ActivityTransferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247.
Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652.
Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115. PMID: 19047066.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses C3bot (154-182) from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: C3bot (154-182), supplier, clostridium, clostridial, C3, protein, neurotrophic, axon, dendrite, outgrowth, transferase-deficient, peptide, fragment, spinal, cord, injury, injuries, c3, bot154-182, Tocris Bioscience, Neuronal Metabolism products
Find multiple products by catalog number
New Products in this Area
Mitochondrial protonophore uncouplerRS 1
High affinity RAD51 activator; also CRISPR enhancer6-Hydroxy-DL-DOPA
Allosteric inhibitor of RAD52; also APE1 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.