Cat. No. 4123
Biological ActivityTransferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.
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References are publications that support the products' biological activity.
Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247.
Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652.
Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115. PMID: 19047066.
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