Rifampicin

Cat. No. 4121

Rifampicin C43H58N4O12 [13292-46-1]

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Alternative Name: Rifampin

Chemical Name: 3-[[(4-Methyl-1-piperazinyl)imino]methyl]-rifamycin

Biological Activity

Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).

Technical Data

M.Wt:
822.94
Formula:
C43H58N4O12
Solubility:
Soluble to 100 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
13292-46-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Hu et al (2010) Pregnane X receptor is SUMOylated to repress the inflammatory response. J.Pharmacol.Exp.Ther. 335 342. PMID: 20719936.

Artsimovitch et al (2005) Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122 351. PMID: 16096056.

Moore et al (2000) Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands. J.Biol.Chem. 275 15122. PMID: 10748001.

Wehrli (1983) Rifampin: mechanisms of action and resistance. Rev.Infect.Dis. 5 S407. PMID: 6356275.

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Keywords: Rifampicin, supplier, bacterial, RNA, polymerase, antibiotics, inhibitors, inhibits, pregnane, x, receptors, PXR, activators, Tocris Bioscience, Pregnane X Receptor Agonist products

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